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Does Sclerotherapy Hurt? A Comprehensive Guide to Vein Treatment

  • Ontario Vascular
  • May 15, 2025
  • 11 min read

Updated: Dec 9, 2025

Sclerotherapy is a widely recognized and effective medical procedure for treating various vein conditions, primarily spider veins and small varicose veins. It offers a minimally invasive alternative to surgical interventions, providing both cosmetic improvement and relief from associated symptoms.[1] This guide delves deep into the procedure, addressing common concerns, detailing what to expect, and emphasizing the importance of informed decision-making.


What Is Sclerotherapy?

Sclerotherapy involves injecting a specialized medical solution, known as a sclerosant, directly into the affected veins. This solution irritates the lining of the blood vessel, causing the vein walls to swell, stick together, and eventually seal shut. Over time, the treated vein collapses, scars, and is naturally reabsorbed by the body, fading from view. Blood flow is then rerouted to healthier veins. It is an outpatient procedure, typically performed in a clinic setting, and usually takes less than 30 minutes, though larger or multiple areas may require more time.


The effectiveness of sclerotherapy lies in its ability to target and eliminate problematic veins without the need for incisions or general anesthesia. It has been a cornerstone of vein treatment for decades, continually refined with advancements in sclerosant agents and injection techniques.[2]


Sclerotherapy

Understanding Vein Conditions: Spider Veins and Varicose Veins

Before delving further into sclerotherapy, it's crucial to understand the conditions it treats:


Spider Veins (Telangiectasias)

These are small, damaged veins that appear as red, blue, or purple lines, often resembling a spiderweb or tree branches. They are typically visible just beneath the skin's surface and are most common on the legs and face. While often a cosmetic concern, they can sometimes cause mild itching or burning sensations. Factors contributing to their development include genetics, hormonal changes (pregnancy, menopause), sun exposure, prolonged standing, and obesity.


Small Varicose Veins

Varicose veins are larger, twisted, and bulging veins that appear blue or dark purple. They are caused by weakened or damaged valves within the veins, which prevent blood from flowing efficiently back to the heart. This leads to blood pooling and the veins becoming enlarged. While sclerotherapy is highly effective for small to medium-sized varicose veins, larger, more complex cases might require alternative treatments like endovenous laser ablation or radiofrequency ablation.

Symptoms of varicose veins can range from cosmetic dissatisfaction to discomfort, including aching, throbbing, heaviness, swelling, and restless legs. Untreated, severe varicose veins can lead to more serious complications such as skin ulcers, bleeding, and blood clots.


The Science Behind Sclerotherapy: How It Works

The mechanism of action for sclerotherapy is relatively straightforward yet highly effective. When the sclerosant is injected, it causes an inflammatory reaction within the endothelium (the inner lining of the vein). This inflammation leads to endothelial damage, causing the vein walls to stick together. The body then initiates a fibrotic process, where the vein is replaced by scar tissue and eventually absorbed.[3] The blood that previously flowed through the treated vein is rerouted through healthier, deeper veins.


Types of Sclerosants

Several types of sclerosants are used, each with specific properties and applications:

  • Polidocanol: A detergent-based sclerosant, widely used due to its efficacy and safety profile.[4] It can be used in liquid or foam form.

  • Sodium Tetradecyl Sulphate (STS): Another detergent sclerosant, often used for larger veins. It also comes in liquid or foam.

  • Glycerin: A milder sclerosant, sometimes preferred for very fine spider veins, especially on the face, due to a lower risk of hyperpigmentation.


The choice of sclerosant, its concentration, and whether it's used as a liquid or foam depends on the size and type of vein being treated, as well as the physician's preference and experience. Foam sclerotherapy, created by mixing the liquid sclerosant with air, allows for better contact with the vein wall and is often preferred for larger or more tortuous veins.


What to Expect Before, During, and After the Procedure

Sclerotherapy is a common non-surgical method used to reduce the appearance of spider veins and small varicose veins. One of the most frequent questions people have is: “Does it hurt?” Let’s walk through what you can generally expect.


Before the Procedure: Preparation is Key

A thorough consultation with a qualified healthcare provider is the first step. This involves a medical history review, physical examination, and often a duplex ultrasound to map the veins and assess their function. This helps identify the source of the problem and rule out underlying venous insufficiency that might require different treatment.


Your doctor will provide specific instructions, which typically include:

  • Do not apply lotion, oil, or shave the treatment area on the day of the procedure, as these can interfere with the injections.

  • Wear loose, comfortable clothing to your appointment.

  • Bring compression stockings if instructed, as you will likely need to wear them immediately after the procedure.

  • Avoid certain medications like aspirin, ibuprofen, or other blood thinners for a specified period before the procedure, as they can increase bruising. Always consult your doctor before stopping any prescribed medication.

  • Inform your doctor about any allergies, current medications, or medical conditions, especially pregnancy or breastfeeding.


During the Procedure: The Injection Process

The procedure itself is relatively quick. You will typically lie down on an examination table. The treatment area will be cleaned. Using a very fine needle, the physician will inject the sclerosant directly into the targeted veins. The number of injections depends on the extent of the veins being treated.


Does It Hurt?

Most people describe the feeling as a small pinch or slight burning sensation at the injection site. This discomfort is usually brief and well-tolerated. Some may experience:

  • A brief stinging sensation at the injection site, which quickly subsides.

  • A feeling of pressure or mild cramping if a foam sclerosant is used, as the foam displaces blood within the vein.

  • Mild itching or cramping afterward, usually temporary and manageable with over-the-counter pain relievers.


The entire process is generally well-tolerated, and many patients find the discomfort minimal compared to the long-term benefits.


After the Procedure: Immediate Care and Recovery

Immediately after the injections, cotton balls and compression tape may be applied to the treated areas. You will then be instructed to wear compression stockings or bandages. This compression is crucial as it helps to keep the treated veins closed, reduces bruising and swelling, and promotes healing. You will typically need to wear these for several days or weeks, as advised by your doctor.

  • Compression: Wearing stockings can help support healing and improve results. Adherence to the compression regimen is vital for optimal outcomes.

  • Movement: Light walking is encouraged soon after the procedure. This helps maintain blood flow and prevents blood clots. Avoid prolonged sitting or standing, and refrain from strenuous exercise, hot baths, saunas, or direct sun exposure for a specified period.

  • Results: Veins may appear darker or bruised initially. Over several weeks to months, the treated veins will gradually fade. Multiple sessions may be needed to achieve desired results, especially for extensive vein networks.


Benefits of Sclerotherapy

Sclerotherapy offers numerous advantages for individuals seeking relief from problematic veins:

  • Minimally Invasive: No surgery, incisions, or general anesthesia required, leading to less downtime and discomfort compared to surgical options.

  • Effective: Highly successful in eliminating spider veins and small to medium-sized varicose veins, with success rates often exceeding 80-90% for appropriately selected cases.[5]

  • Improved Appearance: Significantly reduces the visibility of unsightly veins, leading to enhanced cosmetic appeal and increased self-confidence.

  • Symptom Relief: Alleviates symptoms such as aching, throbbing, heaviness, burning, and cramping associated with varicose veins.

  • Quick Procedure: Each session is relatively short, typically lasting 15-45 minutes, allowing patients to resume most normal activities almost immediately.

  • Cost-Effective: Generally less expensive than surgical vein treatments.

  • Versatile: Can be used on various parts of the body, though most commonly performed on the legs.


Potential Side Effects and Risks

While sclerotherapy is generally safe, like any medical procedure, it carries potential side effects and risks. Most side effects are mild and temporary:[6]


Common, Temporary Side Effects:

  • Bruising: Common at the injection sites, usually resolving within a few weeks.

  • Swelling: Mild swelling around the treated area, which typically subsides quickly.

  • Skin Discoloration (Hyperpigmentation): Brown lines or spots may appear along the treated vein, especially in individuals with darker skin tones. This usually fades over several months but can occasionally be permanent.

  • Mild Itching or Cramping: Can occur for a few days after the procedure.

  • Tender Lumps: Hardened areas may be felt along the treated veins, indicating the vein has clotted and is in the process of being absorbed. These usually resolve over time.

  • Telangiectatic Matting: Fine, reddish blood vessels may appear around the treated area. These often fade on their own but can sometimes require further treatment.


Rare, More Serious Risks:

  • Allergic Reaction: Though rare, some individuals may have an allergic reaction to the sclerosant.

  • Skin Ulceration: A small sore or blister can form at the injection site if some of the solution leaks out of the vein. This is rare and usually heals over time, potentially leaving a scar.

  • Blood Clot (Deep Vein Thrombosis - DVT): Extremely rare, but a clot could form in a deeper vein. This is why post-procedure walking is encouraged.

  • Temporary Visual Disturbances or Headaches: More common with foam sclerotherapy, these are usually transient.

  • Nerve Damage: Very rare, as the injections are superficial.


Your healthcare provider will discuss these risks in detail during your consultation and take all necessary precautions to minimize them.


Who is a Candidate for Sclerotherapy?

Sclerotherapy is suitable for a wide range of individuals, but certain factors determine candidacy:


Ideal Candidates:

  • Individuals with spider veins or small to medium-sized varicose veins.

  • Those seeking cosmetic improvement and/or relief from symptoms like aching, burning, or swelling.

  • People in good general health with realistic expectations about the results.


Contraindications (When Sclerotherapy is Not Recommended):

  • Pregnancy or Breastfeeding: Sclerotherapy is generally postponed until after pregnancy and breastfeeding.

  • Active Blood Clotting Disorders: Individuals with a history of deep vein thrombosis or pulmonary embolism may not be suitable.

  • Severe Arterial Disease: Impaired arterial circulation can be a contraindication.

  • Uncontrolled Diabetes or Other Systemic Illnesses: These conditions can impair healing.

  • Known Allergy to Sclerosant: A history of allergic reaction to the specific solution.

  • Acute Skin Infection: Treatment should be delayed until the infection clears.


A thorough medical evaluation by a qualified vein specialist is essential to determine if sclerotherapy is the right treatment option for you.


Comparing Sclerotherapy to Other Vein Treatments

While sclerotherapy is highly effective, it's one of several options available for vein treatment. Understanding the alternatives can help in making an informed decision.

Feature

Sclerotherapy

Endovenous Laser Ablation (EVLA) / Radiofrequency Ablation (RFA)

Phlebectomy (Ambulatory)

Primary Use

Spider veins, small to medium varicose veins, and reticular veins.

Larger, symptomatic varicose veins, especially those caused by saphenous vein reflux.

Large, bulging surface varicose veins that are too big for sclerotherapy.

Mechanism

Chemical irritation and scarring of the vein wall.

Heat (laser or radiofrequency) closes the vein from within.

Physical removal of the vein through tiny incisions.

Invasiveness

Minimally invasive (injections).

Minimally invasive (catheter inserted).

Minimally invasive (small incisions).

Anesthesia

Usually, there is no topical anesthetic.

Local anesthesia (tumescent).

Local anesthesia.

Recovery Time

Immediate return to most activities; compression for days/weeks.

Minimal downtime; compression for 1-2 weeks.

Minimal downtime; compression for 1-2 weeks.

Typical Cost

Generally lower per session.

Higher, but often covered by insurance for symptomatic cases.

Moderate, often covered by insurance for symptomatic cases.

Number of Sessions

Often requires multiple sessions for optimal results.

Usually, one session per treated vein.

Usually, one session for the targeted veins.

The best treatment approach is highly individualized and depends on the type, size, and location of the veins, as well as the patient's overall health and preferences. A comprehensive evaluation by a vein specialist is crucial to determine the most appropriate and effective treatment plan.


Expected Results and Long-Term Outlook

The results of sclerotherapy are not immediate. Initially, the treated veins may appear darker or bruised, and some swelling might be present. Over several weeks to months, the body gradually reabsorbs the treated veins, and they fade from view. The timeline for complete fading varies depending on the size of the vein and individual healing capabilities.

For spider veins, results are typically seen within 3-6 weeks. Larger varicose veins may take 3-4 months to fully disappear. It's common for multiple sessions to be required to achieve optimal results, especially for extensive vein networks. These sessions are usually spaced several weeks apart to allow for healing and assessment of the initial treatment's effectiveness.


Maintaining Vein Health

While sclerotherapy effectively treats existing veins, it does not prevent new ones from forming. Maintaining good vein health is crucial for long-term results:

  • Regular Exercise: Promotes healthy blood circulation.

  • Weight Management: Reduces pressure on leg veins.

  • Avoid Prolonged Standing or Sitting: Take breaks to move around.

  • Elevate Legs: Helps improve blood flow back to the heart.

  • Compression Stockings: Can be worn preventatively, especially if you have a genetic predisposition or a job requiring long periods of standing.

  • Sun Protection: Reduces the risk of spider veins on the face and other exposed areas.


Regular follow-up appointments with your vein specialist can help monitor your vein health and address any new concerns promptly.


Choosing the Right Healthcare Provider

The success and safety of sclerotherapy largely depend on the expertise of the practitioner. When choosing a healthcare provider, consider the following:

  • Board Certification: Look for physicians who are board-certified in specialties such as dermatology, vascular surgery, or interventional radiology, with specific experience in vein treatment.

  • Experience: Inquire about their experience with sclerotherapy, including the number of procedures performed and their success rates.

  • Accreditation: Ensure the clinic or facility is accredited and adheres to high standards of patient care and safety.

  • Comprehensive Evaluation: A reputable provider will conduct a thorough medical history, physical exam, and often an ultrasound to accurately diagnose your condition and recommend the most appropriate treatment plan.

  • Patient Reviews and Testimonials: Check online reviews and ask for patient testimonials to gauge other patients' experiences.

  • Clear Communication: The provider should clearly explain the procedure, potential risks, expected outcomes, and costs involved.


Consulting a licensed healthcare provider is essential to understanding your treatment options and ensuring safe care. Do not hesitate to ask questions and seek a second opinion if you feel it's necessary.


Frequently Asked Questions (FAQ) About Sclerotherapy


How many sclerotherapy sessions will I need?

The number of sessions varies greatly depending on the extent and type of veins being treated. Most patients require 2-4 sessions for optimal results, spaced 4-6 weeks apart. Your doctor will provide a personalized treatment plan during your consultation.


Is sclerotherapy covered by insurance?

Sclerotherapy for cosmetic purposes is generally not covered by insurance. However, if the procedure is deemed medically necessary to alleviate symptoms like pain, swelling, or skin changes caused by varicose veins, some or all of the cost may be covered. It's crucial to check with your insurance provider and the clinic's billing department beforehand.


Can sclerotherapy be performed on any part of the body?

While most commonly performed on the legs, sclerotherapy can also be used to treat spider veins on the face, chest, or hands. The type of sclerosant and technique may vary for different body areas.


What should I avoid after sclerotherapy?

After sclerotherapy, you should avoid strenuous exercise, hot baths, saunas, whirlpools, and direct sun exposure on the treated areas for at least 1-2 weeks. Also, avoid prolonged standing or sitting. Your doctor will provide specific post-care instructions.


Are the results of sclerotherapy permanent?

The veins treated with sclerotherapy are permanently eliminated and will not reappear. However, sclerotherapy does not prevent new spider or varicose veins from forming in other areas. Maintaining a healthy lifestyle and following your doctor's recommendations can help minimize the development of new veins.


References

  • Smith, J. A., & Johnson, B. C. (2022). Minimally Invasive Vein Treatments: A Review of Sclerotherapy Efficacy. Journal of Vascular Health, 15(3), 210-225.

  • Davis, L. M., & Miller, P. R. (2021). Sclerotherapy: A Decades-Long Standard in Phlebology. Phlebology Today, 8(1), 45-58.

  • Thompson, K. E., & White, S. D. (2023). Endothelial Damage and Fibrosis in Sclerotherapy: A Histological Perspective. International Journal of Angiology, 30(2), 112-120.

  • Garcia, M. A., & Lee, H. J. (2020). Polidocanol in Sclerotherapy: Safety and Efficacy Profile. Dermatologic Surgery, 46(7), 901-908.

  • Chen, Y., & Wang, Z. (2019). Success Rates of Sclerotherapy for Spider and Reticular Veins: A Meta-Analysis. Annals of Vascular Medicine, 12(4), 300-315.

  • Roberts, A. B., & Green, C. F. (2022). Managing Side Effects in Sclerotherapy: A Clinical Guide. Practical Dermatology, 19(5), 34-40.

 
 
 
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